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GPC/SEC Tipps&Tricks
Entwickelt von PSS für LCGC: Praktische Tipps und Ratschläge für GPC/SEC-Benutzer.
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Veröffentlicht
T&T GPC/SEC: How to validate a GPC/SEC system
Validation is not an easy task. It is an ongoing complex process that evaluates the entire, sample specific process, products, and analytical methods and consists of four qualification phases: DQ…
Sprache
Veröffentlichungsnummer
20318
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2010
Veröffentlicht
05.03.2010
Ausgabe
3
Autor
D. Held, C. Trimmer
T&T GPC/SEC: Influence of Sample Dispersity on the GPC/SEC Separation of Multi-Component Systems
This instalment of Tips & Tricks focuses on whether a complete separation can be achieved using GPC/SEC and, if so, under what conditions.
Sprache
Veröffentlichungsnummer
20525
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2021
Veröffentlicht
11.11.2021
Ausgabe
11
Autor
W. Radke, M. Lossa, J. Preis
T&T GPC/SEC: Inter-Detector Delay
Combinations of detectors are often used in gel permeation chromatography/size-exclusion chromatography (GPC/SEC) to measure absolute molar masses or chemical compositions as a function of elution…
Sprache
Veröffentlichungsnummer
20441
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2017
Veröffentlicht
10.08.2017
Ausgabe
8
Autor
D. Held, W. Radke
T&T GPC/SEC: Method Development_
The information and results that are available from detector combinations have been the subject of various Tips&Tricks over the years. Undiscussed up to know was the general impact of detector…
Sprache
Veröffentlichungsnummer
20385
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2012
Veröffentlicht
25.04.2012
Ausgabe
12
Autor
D. Held
T&T GPC/SEC: Method Optimization_
Many scientists consider the development of a GPC/SEC method easy, especially when compared to HPLC applications. This is true in the sense that normally only isocratic conditions are applied, so that…
Sprache
Veröffentlichungsnummer
20387
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2013
Veröffentlicht
24.05.2013
Ausgabe
4
Autor
D. Held
T&T GPC/SEC: Mobile Phase Considerations
There are many sources of advice on how to select the most appropriate stationary phase for sample analysis, but the mobile phase is not often discussed. The mobile phase is an essential and integral…
Sprache
Veröffentlichungsnummer
20418
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2014
Veröffentlicht
02.06.2014
Ausgabe
4
Autor
D. Held
T&T GPC/SEC: New and Old Approaches to Handle Unknown dn/dc in GPC/SEC-LS
The intensity of the light scattering signal depends on concentration, molar mass, and the specifi c refractive index increment, dn/dc, of the sample. dn/dc therefore usually needs to be known to…
Sprache
Veröffentlichungsnummer
20439
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2017
Veröffentlicht
26.10.2017
Ausgabe
10
Autor
W. Radke
T&T GPC/SEC: Particle Size and the Effect of Mixing Columns of Different Particle Size
Gel permeation chromatography/size-exclusion chromatography (GPC/SEC) columns are filled with porous particles differing in particle and pore sizes. Typical particle sizes in analytical GPC/SEC range…
Sprache
Veröffentlichungsnummer
20514
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2020
Veröffentlicht
20.08.2020
Ausgabe
8
Autor
D. Held, W. Radke
T&T GPC/SEC: Polydispersity - How Broad is Broad for Macromolecules?
The vast majority of macromolecules exhibit a molar mass distribution that is often described by the polydispersity index (PDI). This Tips & Tricks instalment offers practical advice to consider when…
Sprache
Veröffentlichungsnummer
20442
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2016
Veröffentlicht
22.12.2016
Ausgabe
12
Autor
D. Held, W. Radke
T&T GPC/SEC: Product Registration and REACH
Molecular mass is one of the central parameters required for product registration. Compared to low molar mass substances, the molar mass determination of macromolecular products is more diffi cult…
Sprache
Veröffentlichungsnummer
20436
Publication Type
Tip&Trick
Quelle
The Column
Jahr
2017
Veröffentlicht
20.06.2017
Ausgabe
6
Autor
D. Held