GPC/SEC Tips&Tricks
Tips&Tricks has been developed by PSS for LC/GC Europe. Since February 2007 it is published bimonthly in LCGC Europe's The Column.
These Tips&Tricks are designed to support GPC/SEC users of in their daily work providing comprehensive overviews on different aspects of this powerful technique.
Many readers collect these publications and approached us for a collection. This resulted in 5 e-books, each book based on 5-8 different Tips & Tricks publications updated with the latest information, new examples and figures.
Please feel free to contact us to receive a pdf. If you miss a topic and want us to elaborate a topic please propose a topic or submit a problem.
Latest publications
Archive
2022
2021
2020
2019
2018
2017
The Column 2 / 2017

Quantify and get more than Molar Mass Averages
The Column 10 / 2017

New and Old Approaches to Handle Unknown dn/dc in GPC/SEC-LS
The Column 4 / 2017

Protein Analysis with Size-Exclusion Chromatography
The Column 12 / 2017

How to Treat Your RI Detector
The Column 6 / 2017

Product Registration and REACH
The Column 8 / 2017

Inter-Detector Delay
2016
The Column 2 / 2016

Upside Down - Inverse GPC for Pore Size Distributions
The Column 10 / 2016

GPC/SEC for Membrane Analysis
The Column 4 / 2016

Flow Marker - An Easy Concept to Increase Reproducibility
The Column 12 / 2016

How Broad is Broad for Macromolecules?
The Column 6 / 2016

Branching Analysis
The Column 8 / 2016

GPC/SEC-Light Scattering: Garbage In, Garbage out
2015
The Column 2 / 2015

Calibration Using Broad Standards
The Column 10 / 2015

How to Care for Your GPC/SEC Instrument
The Column 4 / 2015

How to Determine dn/dc Values
The Column 12 / 2015

Finding the Right Standards
The Column 6 / 2015

Answering Common Questions about GPC/SEC Columns
The Column 8 / 2015

Strategies to Save Solvent
2014
The Column 2 / 2014

How to Install GPC/SEC Columns
The Column 10 / 2014

Sample Recovery and More
The Column 4 / 2014

Mobile Phase Considerations
The Column 12 / 2014

From a Chromatogram to the Molar Mass Distribution
The Column 6 / 2014

The Art of Analyzing High Molar Mass Samples
The Column 8 / 2014

How to test GPC/SEC Columns
2013
The Column 2 / 2013

GPC/SEC do's and don'ts for data analysis
The Column 10 / 2013

Evaporative Light Scattering Detection in GPC/SEC
The Column 4 / 2013

GPC/SEC Method Optimization
The Column 12 / 2013

Select the Right Columns for Your Molar Mass Range
The Column 6 / 2013

Analysis and Calibration for Low Molar Mass Macromolecules
The Column 8 / 2013

An Alternative to Calibration with Narrow Standards
2012
The Column 2 / 2012

GPC/SEC-Viscometry – a Versatile Tool
The Column 10 / 2012

What is the best detector sequence?
The Column 4 / 2012

How to get a stable Baseline
The Column 12 / 2012

GPC/SEC Method Development
The Column 6 / 2012

Result Uncertainty - How reliable are Results?
The Column 8 / 2012

Faster Results
2011
The Column 2 / 2011

Increase Resolution and Separation Range
The Column 10 / 2011

Improving the Reliability of GPC/SEC Light Scattering and Viscometry Results
The Column 4 / 2011

Mass spectrometry as a new solution
The Column 12 / 2011

Is this real? Unexpected Peak Shapes
The Column 7 / 2011

GPC/SEC columns - Dos and Don'ts
The Column 8 / 2011

Sample preparation
2010
The Column 3 / 2010

How to Validate a GPC/SEC System
The Column 10 / 2010

Copolymer Analysis in GPC/SEC 3: 2-dimensional Chromatography
The Column 4 / 2010

UGPC? Making GPC/SEC faster
The Column 12 / 2010

Peak Identification in GPC/SEC
The Column 6 / 2010

Copolymer Analysis in GPC/SEC 1: Compositional analysis by GPC/SEC with multiple detection
The Column 8 / 2010

Copolymer Analysis in GPC/SEC 2: Polymer Liquid Adsorption Chromatography
2009
The Column 02 / 2009

Do’s and Don’ts in GPC/SEC-Light Scattering
The Column 12 / 2009

How to expand the lifetime of columns
The Column 4 / 2009

Choose a Static Light-scattering Technique
The Column 6 / 2009

How does the Flow-rate Influence GPC/SEC Results
The Column 8 / 2009

Temperature Effects in GPC/SEC
2008
The Column 2 / 2008

Accuracy and precision in GPC/SEC
The Column 10 / 2008

Understanding positive and negative detector signals
The Column 4 / 2008

BEWARE of Mismatch
The Column 12 / 2008

A new development in high temperature (HT) GPC/SEC
The Column 6 / 2008

How do I calibrate a GPC/SEC system?
The Column 8 / 2008

What are the applications for (polymer) reference standards?
2007
The Column 2 / 2007

How do I find the optimum sample concentration and injection volume for my GPC/SEC measurements?
The Column 8 / 2007

The importance of molar mass distributions
The Column 10 / 2007

A look at the importance of molar mass averages.
The Column 12 / 2007

How to find the ideal stationary GPC/SEC separation phase?