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GPC/SEC Tips&Tricks

Tips&Tricks has been developed by PSS for LC/GC Europe. Since February 2007 it is published bimonthly in LCGC Europe's The Column.

These Tips&Tricks are designed to support GPC/SEC users of in their daily work providing comprehensive overviews on different aspects of this powerful technique.

Many readers collect these publications and approached us for a collection. This resulted in 5 e-books, each book based on 5-8 different Tips & Tricks publications updated with the latest information, new examples and figures.

Please feel free to contact us to receive a pdf. If you miss a topic and want us to elaborate a topic please propose a topic or submit a problem.

Latest publication

The Column 12 / 2019


"Green" GPC/SEC and Solvent Alternatives

Archive

2019

The Column 2 / 2019


System Peaks or Ghost Peaks in GPC/SEC

The Column 10 / 2019


Systematic errors in GPC/SEC/GFC

The Column 4 /2019


Column Issues with Light Scattering Detectors

The Column 6 / 2019


How GPC/SEC Can Help to Reduce PET Plastic Waste

The Column 8 / 2019


High Temperature GPC versus ambient GPC

2018

The Column 4 / 2018


How Do Calibration Curves Influence GPC/SEC Results?

The Column 12 / 2018


What you need to know to allow for efficient GPC/SEC Troubleshooting

 

The Column 6 / 2018


Aqueous GPC/SEC: Influence of Salt and pH

The Column 8 / 2018


UV-vis Detection

The Column 10 / 2018


What are differences between GPC, SEC and GFC and how to get started?

2017

The Column 2 / 2017


Quantify and get more than Molar Mass Averages

The Column 10 / 2017


New and Old Approaches to Handle Unknown dn/dc in GPC/SEC-LS

The Column 4 / 2017


Protein Analysis with Size-Exclusion Chromatography

The Column 12 / 2017


How to Treat Your RI Detector

The Column 6 / 2017


Product Registration and REACH

The Column 8 / 2017


Inter-Detector Delay

2016

The Column 2 / 2016


Upside Down - Inverse GPC for Pore Size Distributions

The Column 10 / 2016


GPC/SEC for Membrane Analysis

The Column 4 / 2016


Flow Marker - An Easy Concept to Increase Reproducibility

The Column 12 / 2016


How Broad is Broad for Macromolecules?

The Column 6 / 2016


Branching Analysis

The Column 8 / 2016


GPC/SEC-Light Scattering: Garbage In, Garbage out

2015

The Column 2 / 2015


Calibration Using Broad Standards

The Column 10 / 2015


How to Care for Your GPC/SEC Instrument

The Column 4 / 2015


How to Determine dn/dc Values

The Column 12 / 2015


Finding the Right Standards

The Column 6 / 2015


Answering Common Questions about GPC/SEC Columns

The Column 8 / 2015


Strategies to Save Solvent

2014

The Column 2 / 2014


How to Install GPC/SEC Columns

The Column 10 / 2014


Sample Recovery and More

The Column 4 / 2014


Mobile Phase Considerations

The Column 12 / 2014


From a Chromatogram to the Molar Mass Distribution

The Column 6 / 2014


The Art of Analyzing High Molar Mass Samples

The Column 8 / 2014


How to test GPC/SEC Columns

2013

The Column 2 / 2013


GPC/SEC do's and don'ts for data analysis

The Column 10 / 2013


Evaporative Light Scattering Detection in GPC/SEC

The Column 4 / 2013


GPC/SEC Method Optimization

The Column 12 / 2013


Select the Right Columns for Your Molar Mass Range

The Column 6 / 2013


Analysis and Calibration for Low Molar Mass Macromolecules

The Column 8 / 2013


An Alternative to Calibration with Narrow Standards

2012

The Column 2 / 2012


GPC/SEC-Viscometry – a Versatile Tool

The Column 10 / 2012


What is the best detector sequence?

The Column 4 / 2012


How to get a stable Baseline

The Column 12 / 2012


GPC/SEC Method Development

The Column 6 / 2012


Result Uncertainty - How reliable are Results?

The Column 8 / 2012


Faster Results

2011

The Column 2 / 2011


Increase Resolution and Separation Range

The Column 10 / 2011


Improving the Reliability of GPC/SEC Light Scattering and Viscometry Results

The Column 4 / 2011


Mass spectrometry as a new solution

The Column 12 / 2011


Is this real? Unexpected Peak Shapes

The Column 7 / 2011


GPC/SEC columns - Dos and Don'ts

The Column 8 / 2011


Sample preparation

2010

The Column 3 / 2010


How to Validate a GPC/SEC System

 

The Column 10 / 2010


Copolymer Analysis in GPC/SEC 3: 2-dimensional Chromatography

The Column 4 / 2010


UGPC? Making GPC/SEC faster

 

The Column 12 / 2010


Peak Identification in GPC/SEC

The Column 6 / 2010


Copolymer Analysis in GPC/SEC 1: Compositional analysis by GPC/SEC with multiple detection

The Column 8 / 2010


Copolymer Analysis in GPC/SEC 2: Polymer Liquid Adsorption Chromatography

2009

The Column 02 / 2009


Do’s and Don’ts in GPC/SEC-Light Scattering

 

The Column 12 / 2009


How to expand the lifetime of columns

The Column 4 / 2009


Choose a Static Light-scattering Technique

 

The Column 6 / 2009


How does the Flow-rate Influence GPC/SEC Results

The Column 8 / 2009


Temperature Effects in GPC/SEC

2008

The Column 2 / 2008


Accuracy and precision in GPC/SEC

 

The Column 10 / 2008


Understanding positive and negative detector signals

The Column 4 / 2008


BEWARE of Mismatch


 

The Column 12 / 2008


A new development in high temperature (HT) GPC/SEC

The Column 6 / 2008


How do I calibrate a GPC/SEC system?

The Column 8 / 2008


What are the applications for (polymer) reference standards?

2007

The Column 2 / 2007


How do I find the optimum sample concentration and injection volume for my GPC/SEC measurements?

 

The Column 8 / 2007


The importance of molar mass distributions

The Column 10 / 2007


A look at the importance of molar mass averages.

The Column 12 / 2007


How to find the ideal stationary GPC/SEC separation phase?

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